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Details of Grant 

EPSRC Reference: GR/S90751/01
Title: Advances in Diffusion-Ordered NMR Spectroscopy.
Principal Investigator: Morris, Professor GA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Manchester, The
Scheme: Standard Research (Pre-FEC)
Starts: 01 May 2004 Ends: 30 April 2007 Value (£): 184,424
EPSRC Research Topic Classifications:
Analytical Science Chemical Biology
Instrumentation Eng. & Dev.
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Chemicals
Food and Drink
Related Grants:
Panel History:  
Summary on Grant Application Form
NMR spectroscopy is the chemists tool of choice for determining molecular structure. It is a wonderfully versatile and sensitive tool, but it has one glaring fault it is poor at analysing mixtures, so it is mostly used on carefully purified single compounds. Diffusion-ordered spectroscopy (DOSY) gets round this limitation by separating signals from different molecules according to size, and over the last 10 years our research group and others have developed the technique and applied it with great success - but mostly to comparatively simple mixtures. In this project, a postdoctoral research fellow will investigate some novel experimental methods to widen the range of problems in chemistry, biochemistry and medicine that DOSY can solve, by enabling us to tackle more complex mixtures which give severrely overcrowded NMR spectra. The new experiments incorporate extra NMR information such as relaxation rates into the experimental data, making them much more specific and enabling the signals from individual chemical species to be separated much more efficiently. Potential applications range from picking out the active compounds in a mixture of potential drugs, through tracking the chemical changes as vintage port ages, to analysing body fluids to determine how the body deals with new medicines.
Key Findings
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Potential use in non-academic contexts
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Summary
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Project URL: http://nmr.chemistry.manchester.ac.uk/
Further Information:  
Organisation Website: http://www.man.ac.uk