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Details of Grant 

EPSRC Reference: GR/S23513/01
Title: Basic Technology: 4 Billion Bases a Day - Practical Individual Genome Sequencing
Principal Investigator: Morgan, Professor H
Other Investigators:
Bradley, Professor M Prugel-Bennett, Professor A Nandhakumar, Dr IS
Welsh, Professor A Roach, Professor P Zheludev, Professor N
Essex, Professor JW Neylon, Dr C Neylon, Dr C
Researcher Co-Investigators:
Project Partners:
Department: School of Chemistry
Organisation: University of Southampton
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2003 Ends: 30 September 2008 Value (£): 2,608,219
EPSRC Research Topic Classifications:
Analytical Science Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
The proposal described below is fundamentally a new method of synthesising, screening and sequencing DNA at a rate that is thousands of time,, faster than existing methods. If successful it will allow over 4 billion bases to be sequenced in less than a day on one instrument! The magnitude what is being proposed here is quite literally mind-boggling and will cause a revolution in all areas of human health forever changing the landscape biological and medicinal sciences. En route spin off applications will include the rapid and comprehensive identification of all single base changes a given person's genome, the ability to analyse large numbers of people for the presence of single changes at an unprecedented rate, a method fl rapidly and cheaply producing huge numbers (100,000s) of defined oligonucleotide sequences, and the use of this methodology to change curren array technology as well as the ultimate aim of sequencing billions of bases a day.
Key Findings
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Impacts
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Summary
Date Materialised
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Project URL:  
Further Information:  
Organisation Website: http://www.soton.ac.uk