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Details of Grant 

EPSRC Reference: GR/R28911/01
Title: Support and Enhancement For X-Ray Microtomography Faclity For Study Bone, Tooth and Engineering Materials
Principal Investigator: Elliott, Professor JC
Other Investigators:
Dowker, Dr SEP Boyde, Professor A Lee, Professor PD
Derby, Professor B Mummery, Professor P Hing, Dr K
Zioupos, Professor P Taylor, Professor M Mummery, Dr P
Davis, Professor GR Anderson, Professor P Wong, Dr F
Samarawickrama, Dr D Goodship, Professor A Wilkinson, Professor AJ
Tanner, Professor KE
Researcher Co-Investigators:
Project Partners:
Department: Sch of Medicine & Dentistry
Organisation: Queen Mary University of London
Scheme: Standard Research (Pre-FEC)
Starts: 01 July 2001 Ends: 31 December 2004 Value (£): 154,327
EPSRC Research Topic Classifications:
Biomaterials Instrumentation Eng. & Dev.
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
12 Mar 2001 Metrology For Life Sciences Deferred
Summary on Grant Application Form
A 3-dimensional X-ray microtomographic microscope facility will be established and used in a wide range of multidisciplinary studies of bones, teeth, and engineering materials. This form of microscopy is nondestructive and is a miniaturised form of the well-known medical CT scanner. It will give the required detail in 3-dimensions to a resolution of 5 microns for specimens with maximum dimensions of 50mm diameter by 60mm long. For many of the studies, changes in 3D structure wilt be recorded whilst the specimen is subjected to an applied load, or change in humidity, liquid environment or temperature. Both the static and dynamic observations will give detailed information about the specimen that cannot be obtained by any other methods. The dental studies will be relevant to the physicochemical mechanisms, diagnosis and treatment of caries, an extremely prevalent disease that is a major cost to the country. The micromechanical and microstructural studies of bone and bone implants will be used to futher understanding of bone in degenerative diseases of the skeleton (osteoporosis and osteoarthritis) with the aim of improving diagnosis and treatment. These diseases are costly and cause great distress to patients, for example, one in three women and one in twelve men suffer from osteoporosis and a high proportion of these individuals sustain fractures. Investigations of the engineering materials will focus on the fundamental relationships beween microstructure, deformation processes and mechanical properties of alloys, inorganic foams and composites.
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