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Details of Grant 

EPSRC Reference: GR/N20546/01
Title: DEVELOPMENT OF TOFSIMS INSTRUMENTATION AND METHODOLOGY FOR CHEMICAL OF CELLULAR SYSTEMS
Principal Investigator: Vickerman, Professor JC
Other Investigators:
Stephens, Professor G Lockyer, Dr NP
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Manchester, The
Scheme: Standard Research (Pre-FEC)
Starts: 01 May 2000 Ends: 30 April 2003 Value (£): 328,262
EPSRC Research Topic Classifications:
Cells Chemical Biology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
Biochemical studies provide the key to understanding and exploiting microorganisms and also, crucially, the control of infectious deseases. There is a critical requirement to develop tools to allow cell biologists to study complex chemistry within individual cells. The propsed research is the culmination of four years EPSRC funded instrument development from which a high sensitivity chemical microscope (ToFSIMS) has evolved with the analytical capability to probe complex chemistry with high magnification and high sensitivity. In collaboration with microbiologists, a three year project is now proposed which plans to advance the instrumentation specifically for cellular analysis and validate ToFSIMS for the first time in microbial cell chemistry research. Funds are requested to provide the necessary hardware (freeze-fracture facilities and essential upgrade to our post-ionisation laser system), for consumables, to support a microbiologist post-doctoral research associate and postgraduate research student and cover technician costs.
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Further Information:  
Organisation Website: http://www.man.ac.uk