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Details of Grant 

EPSRC Reference: EP/R011230/1
Title: Flexible Raman biosensing platform for low-cost health diagnostics
Principal Investigator: Wilkinson, Professor JS
Other Investigators:
Zervas, Professor M Read, Professor RC Bartlett, Professor PN
Researcher Co-Investigators:
Project Partners:
Defence Science & Tech Lab DSTL
Department: Optoelectronics Research Centre
Organisation: University of Southampton
Scheme: Standard Research
Starts: 01 January 2018 Ends: 30 June 2021 Value (£): 972,878
EPSRC Research Topic Classifications:
Analytical Science Med.Instrument.Device& Equip.
Scattering & Spectroscopy
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
11 Sep 2017 HT Investigator-led Panel Meeting - September 2017 Announced
Summary on Grant Application Form
Highly specific, sensitive sensors interfaced with portable, easy-to use, low-cost instruments are needed for rapid point-of-care infection diagnostics, and will lead to better targeted therapy, shorter time to treatment and reduced morbidity. In this project, we propose to realise a generic, flexible, compact sensing platform with high sensitivity and selectivity. The system will comprise a low-cost instrument employing cheap, disposable generic sensor chips that can be readily committed to specific analytes, from small molecules to proteins and DNA, by using conventional surface modification techniques. Paper-based fluidics will be used to deliver analytes straightforwardly from a drop to the sensor surface or, where required, fluidic microsystems may be easily integrated. The sensing system will be demonstrated with clinical samples from patients who have been exposed to controlled infection to whooping cough and for the analysis of priority pathogens such as ebola and plague. This proposal builds upon our recent work on waveguide-enhanced Raman spectroscopy (WERS) to realise a sensor chip which shows surface enhancements comparable to those of surface enhanced Raman spectroscopy (SERS) with improved application flexibility and manufacturability, and upon joint work between Dstl and Chemistry on surface enhanced Raman approaches to bioanalyte detection. The proposed biosensing platform will have widespread application at the point of care for patients, in the detection of infection and the diagnosis of disease, and for broader applications such as environmental monitoring and security, and will be flexibly configurable for specific settings and analytical challenges. The desktop instrument, employing plug-in disposable sensor chips with simple operation will be appropriate for use in the GP's surgery, the ward, or in remote communities.

Key Findings
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Potential use in non-academic contexts
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Summary
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Further Information:  
Organisation Website: http://www.soton.ac.uk