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Details of Grant 

EPSRC Reference: EP/R003971/1
Title: Enhanced surgical treatments for hip osteoarthritis
Principal Investigator: Williams, Dr S
Other Investigators:
Harris, Professor RA Kay, Dr R
Researcher Co-Investigators:
Project Partners:
Depuy Synthes Leeds Teaching Hospitals NHS Trust Simulation Solutions
Thayer School of Engineering at Dartmout
Department: Mechanical Engineering
Organisation: University of Leeds
Scheme: Standard Research
Starts: 01 December 2017 Ends: 30 November 2022 Value (£): 1,021,819
EPSRC Research Topic Classifications:
Biomechanics & Rehabilitation
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
18 Sep 2017 Healthcare Technologies Challenge Awards 2 Interviews (Panel A) September 2017 Announced
28 Jun 2017 Healthcare Technologies Challenge Awards 28 June 2017 Announced
Summary on Grant Application Form
Over 80 million patients worldwide suffer from hip osteoarthritis, and increasing numbers of patients are requiring total hip replacement surgery. This is considered to be a successful intervention, however, an ageing population with increasing orthopaedic treatment needs, greater levels of obesity and patient expectations, and reducing healthcare budgets and surgical training are conspiring to challenge this success. There is also increasing demand for surgical treatments in younger patients that will delay the need for hip replacement surgery, these interventions reshape bone and repair soft tissue.

One of the major causes of failure in the natural hip and in hip replacements is impingement, where there is a mechanical abutment between bone on the femoral side and hip socket or hip replacement components. In the natural hip, surgery reshaping the bone can reduce this impingement and soft tissue damage can be repaired; however, the effects of the amount of bone that is removed is not well understood nor is the best way to repair soft tissue. The number of hip replacements needing to be removed from patients and replaced with a new one in revision surgery is increasing; damage to the cup rim because of impingement is often implicated. It is known that this is more likely if the components are not well aligned relative to each another, or relative to the load direction experienced in the body.

In this proposal, I seek to ensure long term outcomes of early intervention and hip replacement surgery are always optimum by negating concerns about impingement. To do this, I will develop an experimental anatomical hip simulator. The simulator will apply loads and motions to the hip similar to those observed clinically, and include high fidelity phantoms that mimic the natural hip, into which hip replacement components can also be implanted.

This anatomical simulator will be used to assess how variables such as those associated with the patient (e.g. their bony geometry), the extent of early intervention surgery (e.g. the amount of bone removed) or the design of the prosthesis and how the hip is aligned in the body will affect the likelihood of impingement. This improved understanding of factors affecting the likelihood and severity of impingement will enable better guidance on how the surgery should be performed to optimise outcomes to be provided.



I will work with orthopaedic surgeons to integrate this improved understanding into their clinical practice and with an orthopaedic company to integrate the findings into new product development processes; so that future interventions and devices can be designed to provide better outcomes for all patients.

Key Findings
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Potential use in non-academic contexts
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Summary
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Organisation Website: http://www.leeds.ac.uk