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Details of Grant 

EPSRC Reference: EP/P02985X/1
Title: Aluminium nitride - graphene dual-mode sensors for cancer cell detection
Principal Investigator: Klein, Professor N
Other Investigators:
Petrov, Dr PK Dunlop, Dr I Lischner, Dr J
Jiao, Professor LR
Researcher Co-Investigators:
Project Partners:
EVA Diagnostics ltd Link Microtek ltd
Department: Materials
Organisation: Imperial College London
Scheme: Standard Research
Starts: 01 October 2017 Ends: 30 September 2020 Value (£): 1,158,109
EPSRC Research Topic Classifications:
Bioelectronic Devices Materials Characterisation
Med.Instrument.Device& Equip. Medical science & disease
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
12 Apr 2017 Engineering Prioritisation Panel Meeting 12 April 2017 Announced
Summary on Grant Application Form
We propose to develop a technology for wafer scale device fabrication based on thin film heterostructures composed of graphene and aluminium nitride (AlN), which were recently demonstrated by our team for the first time. As a new orthogonal approach for biosensors, AlN-graphene heterostructures should enable simultaneous mass and charge detection of immobilized cellular and molecular species within one integrated device. This new capability is expected to lead to a dramatic reduction of false positives and false negatives in cancer cell detection based on antigen-antibody bond-mediated cell capturing. : As a bioactive sensor surface, bio-functionalized graphene enables charge detection via the electric field effect in graphene. Simultaneously, the graphene biointerface layer will be employed as an electrode - in combination with other graphene layer(s) embedded inside the heterostructure - to enable a fully integrated piezoelectric excitation and readout of mechanical deformations or oscillations of a free-standing AlN structure. Cell capture-induced alterations of the deformation or mechanical resonance should allow mass detection of the immobilized species. This orthogonal sensing capability of fully integrated devices will be tested and benchmarked for detection of cancer cells in blood or other body fluids.
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Organisation Website: http://www.imperial.ac.uk